交付项目:
1) Design documentations for a large FOV and high resolution imaging module, an efficient and robust focus searching algorithm, and a fast and precise auto focusing module
2) A prototype of the large FOV, high resolution imaging module and its performance comparison to a commercial slide digitization system.
3) An efficient and robust focus-searching algorithm for fast auto focusing needed in high throughput slide digitization systems.
4) A prototype of a fast and precise actuation module to realize the developed auto focusing algorithm, and its performance comparison to a commercial slide digitization system.
5) Licensable imaging and focusing technologies including at least two invention/patent disclosures.
6) A large-scale slide digitization and digital pathology diagnosis trial with two hospitals.
描述:
數位化病理包含對病理切片進行數位化成像，管理和診斷。相較于傳統的基於光學顯微鏡和玻璃切片的診斷方式，數位化病理不但對病理醫師們進行遠端診斷提供了支援，而且支援病理醫師運用各種圖像分析軟體進行更加定量和客觀診斷。基於以上優點，數位化病理將引起病理診斷的革新，從而帶給大眾更快更好的醫療服務。然而，由於一些技術上的障礙，例如過長的數位成像時間和較大的圖像資料量，以及高昂的價格，現階段數位化病理診斷還沒有得到廣泛普及。 此專案的目的是開發新的技術用以提高病理切片數位成像速度。我們研究的重點將集中於兩個方向。 一：大視野高分辨成像系統的光學設計，用以減少全幅切片成像需要的局部成像次數；二：快速回應的自動對焦系統的力學設計，用以減少全幅切片對焦所需的時間。
